Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration
نویسندگان
چکیده
منابع مشابه
Redox Regulation of Cysteine-Dependent Enzymes in Neurodegeneration
Evidence of increased oxidative stress has been found in various neurodegenerative diseases and conditions. While it is unclear whether oxidative stress is a cause or effect, protein, lipid, and DNA have all been found to be susceptible to oxidant-induced modifications that alter their function. Results of clinical trials based on the oxidative-stress theory have been mixed, though data continu...
متن کاملCysteine-based redox switches in enzymes.
The enzymes involved in metabolism and signaling are regulated by posttranslational modifications that influence their catalytic activity, rates of turnover, and targeting to subcellular locations. Most prominent among these has been phosphorylation/dephosphorylation, but now a distinct class of modification coming to the fore is a set of versatile redox modifications of key cysteine residues. ...
متن کاملRedox-dependent transcriptional regulation.
Reactive oxygen species contribute to the pathogenesis of a number of disparate disorders including tissue inflammation, heart failure, hypertension, and atherosclerosis. In response to oxidative stress, cells activate expression of a number of genes, including those required for the detoxification of reactive molecules as well as for the repair and maintenance of cellular homeostasis. In many ...
متن کاملThe Direct Electrochemical Investigation of Redox Enzymes
Even though the use of enzymes as useful analytical reagents when immobilized onto a transducer such as an electrochemical device has been reported in the literature for nearly two decades, the direct, i.e. unmediated electrochemistry of enzymes is, nevertheless, a rather recent development. Efforts will be made to introduce the fundamental basis for protein-surface interactions with emphas...
متن کاملRedox regulation by glutathione needs enzymes
1 Department of Neurology, Medical Faculty, Heinrich-Heine Universität, Düsseldorf, Germany 2 Institute for Medical Biochemistry and Molecular Biology, University Medicine, Ernst-Moritz-Arndt Universität, Greifswald, Germany 3 Departamento de Bioquímica, Universidad de la República, Montevideo, Uruguay 4 Department of Chemistry, University of Padova, Padova, Italy *Correspondence: carsten.bernd...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Cell Biology
سال: 2012
ISSN: 1687-8876,1687-8884
DOI: 10.1155/2012/703164